A multicentre case control study on complicated coeliac disease: two different patterns of natural history, two different prognoses.
- Authors: Biagi, F.; M. A. R. C. H. E. S. E., A.; Ferretti, F.; Ciccocioppo, R.; Schiepatti, A.; Volta, U.; Caio, G.; Ciacci, C.; Zingone, F.; D'Odorico, A.; Carroccio, A.; Ambrosiano, G.; Mansueto, P.; Gasbarrini, A.; Piscaglia, A.; Andrealli, A.; Astegiano, M.; Segato, S.; Neri, M.; Meggio, A.; De Pretis, G.; De Vitis, I.; Gobbi, P.; Corazza, G.
- Publication year: 2014
- Type: Articolo in rivista (Articolo in rivista)
- OA Link: http://hdl.handle.net/10447/95983
Abstract
Background: Coeliac disease is a common enteropathy characterized by an increased mortality mainly due to its complications. The natural history of complicated coeliac disease is characterised by two different types of course: patients with a new diagnosis of coeliac disease that do not improve despite a strict gluten-free diet (type A cases) and previously diagnosed coeliac patients that initially improved on a gluten-free diet but then relapsed despite a strict diet (type B cases). Our aim was to study the prognosis and survival of A and B cases.Methods: Clinical and laboratory data from coeliac patients who later developed complications (A and B cases) and sex- and age-matched coeliac patients who normally responded to a gluten-free diet (controls) were collected among 11 Italian centres.Results: 87 cases and 136 controls were enrolled. Complications tended to occur rapidly after the diagnosis of coeliac disease and cumulative survival dropped in the first months after diagnosis of ...