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MAURIZIO BRUNO

The cytotoxic properties of Natural Coumarins Isolated from roots of Ferulago campestris (Apiaceae) and of synthetic ester derivatives aegelinol

  • Authors: Rosselli, S; Maggio, AM; Faraone, N; Spadaro, V; Morris-Natschke, SL; Bastow, KF; Lee, KH; Bruno, M
  • Publication year: 2009
  • Type: Articolo in rivista (Articolo in rivista)
  • Key words: Apiaceae, Ferulago campestris, coumarins, aegelinol derivatives, cytotoxicity
  • OA Link: http://hdl.handle.net/10447/46012

Abstract

Grandivittin (1), agasyllin (2), aegelinol benzoate (3) and felamidin (20), four natural coumarins isolated from Ferulago campestris, and several synthetic ester derivatives of aegelinol (4) were tested against four tumor cell lines. Some of them were shown to be marginally cytotoxic against the A549 lung cancer cell line.