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GIAMPAOLO BARONE

Selective targeting of PARP-1 zinc finger recognition domains with Au(III) organometallics

  • Authors: Wenzel, Margot N.; Meier-Menches, Samuel M.; Williams, Thomas L.; Rämisch, Eberard; Barone, Giampaolo; Casini, Angela*
  • Publication year: 2018
  • Type: Articolo in rivista (Articolo in rivista)
  • OA Link: http://hdl.handle.net/10447/267054

Abstract

The binding of Au(iii) complexes to the zinc finger domain of the anticancer drug target PARP-1 was studied using a hyphenated mass spectrometry approach combined with quantum mechanics/molecular mechanics (QM/MM) studies. Competition experiments were carried out, whereby each Au complex was exposed to two types of zinc fingers. Notably, the cyclometallated Au-C^N complex was identified as the most selective candidate to disrupt the PARP-1 zinc finger domain, forming distinct adducts compared to the coordination compound Auphen.