Tumor infiltration by chemokine receptor 7 (CCR7)+ T-lymphocytes is a favorable prognostic factor in metastatic colorectal cancer
- Authors: Correale P.; Rotundo M.S.; Botta C.; Vecchio M.T.D.; Tassone P.; Tagliaferri P.
- Publication year: 2012
- Type: Articolo in rivista
- OA Link: http://hdl.handle.net/10447/512507
Abstract
The immune interactions occurring within the tumor microenvironment have a critical role in determining the outcome of colorectal cancer patients. We carried-out an immunohistochemical analysis of tumor infiltrating T-lymphocytes expressing chemokine receptor 7 (CCR7) in a series of colorectal cancer patients enrolled in a prospective clinical trial. We demonstrated that a high tumor infiltration score of this lymphocyte subset is predictive of longer progression free survival and overall survival. © 2012 Landes Bioscience.