Genetically determined hypercholesterolaemia results into premature leucocyte telomere length shortening and reduced haematopoietic precursors
- Authors: Baragetti, Andrea; Bonacina, Fabrizia; Da Dalt, Lorenzo; Moregola, Annalisa; Zampoleri, Veronica; Pellegatta, Fabio; Grigore, Liliana; Pirillo, Angela; Spina, Rossella; Cefalù', Angelo Baldassare; Averna, Maurizio; Norata, Giuseppe D; Catapano, Alberico L
- Publication year: 2020
- Type: Articolo in rivista
- OA Link: http://hdl.handle.net/10447/522500
Abstract
Leucocyte telomere length (LTL) shortening is a marker of cellular senescence and associates with increased risk of cardiovascular disease (CVD). A number of cardiovascular risk factors affect LTL, but the correlation between elevated LDL cholesterol (LDL-C) and shorter LTL is debated: in small cohorts including subjects with a clinical diagnosis of familial hypercholesterolaemia (FH). We assessed the relationship between LDL-C and LTL in subjects with genetic familial hypercholesterolaemia (HeFH) compared to those with clinically diagnosed, but not genetically confirmed FH (CD-FH), and normocholesterolaemic subjects.