Antiproliferative Oleanane Saponins from Meryta denhamii
- Authors: CIOFFI, G; DAL PIAZ, F; VASSALLO, A; VENTURELLA, F; DE CAPRARIIS, P; DE SIMONE, F; DE TOMMASI, N
- Publication year: 2008
- Type: Articolo in rivista (Articolo in rivista)
- Key words: Oleanane Saponins, Antiproliferative effects
- OA Link: http://hdl.handle.net/10447/38990
Abstract
Eight new oleanane saponins (1- 8) together with four know saponins (9-12) were isolated from the aerial parts of Meryta denhamii. Their structures were elucidated by 1D and 2D NMR experiments including 1D TOCSY, DQF-COSY, ROESY, HSQC, and HMBC spectroscopy, as well as ESIMS analysis. The antiproliferative activity of all compounds was evaluated using three murine and human cancer cell lines: J774.A1, HEK-293, and WEHI-164.