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GIUSEPPE PISTONE

Vitiligo susceptibility and catalase gene (CAT) polymorphisms in sicilian population

  • Authors: Caputo, Valentina; Niceta, Marcello; Fiorella, Santi; La Vecchia, Marco; Bastonini, Emanuela; Bongiorno, Maria R; Pistone, Giuseppe
  • Publication year: 2018
  • Type: Articolo in rivista
  • OA Link: http://hdl.handle.net/10447/514735

Abstract

Catalase gene (CAT) polymorphisms were analyzed as responsible for the deficiency of catalase enzyme activity and concomitant accumulation of excessive hydrogen peroxide in Vitiligo patients. Catalase is a well known oxidative stress regulator that could play an important role in the pathogenesis of Vitiligo. This study was conducted to evaluate three CAT gene polymorphisms (-89A/T, 389C/T, 419C/T) and their association with Vitiligo susceptibility in Sicilian population.