Association between hypovitaminosis D and systemic sclerosis: True or fake?
- Authors: Bivona, G.; Agnello, L.; Pivetti, A.; Milano, S.; Scazzone, C.; Lo Sasso, B.; Ciaccio, M.
- Publication year: 2016
- Type: Review essay (rassegna critica) (Articolo in rivista)
- OA Link: http://hdl.handle.net/10447/206263
Abstract
Background: Vitamin D insufficiency/deficiency is considered a major factor triggering and enhancing several autoimmune disorders; hypovitaminosis D has been reported to be common in Systemic Sclerosis (SSc). Previous studies assessing vitamin D insufficiency/deficiency in SSc have been reviewed, and the relation with pathogenesis and clinical features has been examined. Content: Eligibility criteria were: reporting measurement of Vitamin D serum levels in all participants and evaluating adult onset-SSc individuals as patients group. Results: The association between clinical features and low hormone levels is controversial. Manifold data have shown vitamin D insufficiency/deficiency to have a potential role in the pathogenesis of disease, providing inconclusive findings. Summary: Promoting the onset of SSc depends on the interaction between genetics, environment and infections. It remains a sound question whether Vitamin D insufficiency/deficiency is an environment-linked immunological heckler, making infectious agents taking root.