Development and characterization of xyloglucan-poly(vinyl alcohol) hydrogel membrane for Wireless Smart wound dressings

Abstract

Hydrogel-based smart wound dressings that combine the traditional favourable properties of hydrogels as skin care materials with sensing functions of relevant biological parameters for the remote monitoring of wound healing are under development. In particular, lightweight, ultra-high frequency radiofrequency identification (UHF RFID) sensor are adjoined to xyloglucan-poly(vinyl alcohol) hydrogel films to battery-less monitor moisture level of the bandage in contact with the skin, as well as wireless transmit the measured data to an off-body reader. This study investigates the swelling behavior of the hydrogels in contact with simulated biological fluids, and the modification of their morphology, mechanical properties, and dielectric properties in a wide range of frequencies (100–106Hz and 108–1011Hz). The films absorb simulated body fluids up to approximately four times their initial weight, without losing their integrity but undergoing significant microstructural changes. We observed relevant linear increases of electric conductivity and permittivity with the swelling degree, with an abrupt change of slope that is related to the network rearrangements occurring upon swelling.