Trends of colorectal cancer incidence and mortality rates from 2003 to 2014 in Italy
- Autori: Zorzi M.; Dal Maso L.; Francisci S.; Buzzoni C.; Rugge M.; Guzzinati S.; Mazzoleni G.; Coviello E.; Galasso R.; Sampietro G.; Magoni M.; Ardizzone A.; D'Argenzio A.; Sutera Sardo A.; Giorno A.; La Greca G.; Ricci P.; Ferretti S.; Palma F.; Serraino D.; Iacovacci S.; Melcarne A.; Puppo A.; Sciacca S.; Russo A.G.; Caruso B.; Cavalieri d'Oro L.; D'Orsi G.; Fusco M.; Usala M.; Vitale F.; Cusimano R.; Michiara M.; Boschetti L.; Chiaranda G.; Rosso S.; Tumino R.; Mangone L.; Falcini F.; Caiazzo A.L.; Cesaraccio R.; Tisano F.; Fanetti A.C.; Minerba S.; Caldarella A.; Candela G.; Piffer S.; Cania A.; Castelli M.; Pisani M.; Tagliabue G.; Bovo E.; Brustolin A.
- Anno di pubblicazione: 2019
- Tipologia: Articolo in rivista
- Parole Chiave: Colorectal cancer; incidence; mortality; screening; Age Factors; Aged; Colorectal Neoplasms; Female; Humans; Italy; Male; Middle Aged; Registries; Sex Characteristics
- OA Link: http://hdl.handle.net/10447/401635
Objective: To evaluate the trends of colorectal cancer (CRC) incidence and mortality rates from 2003 to 2014 in Italy by age groups and regions. Methods: We used the data of 48 cancer registries from 17 Italian regions to estimate standardized incidence and mortality rates overall and by sex, age groups (<50, 50–69, 70+ years), and geographic area (northwest, northeast, center, south, and islands). Time trends were expressed as annual percent change in rates (APC) with 95% confidence intervals (95% CI). Results: Incidence rates decreased from 104.3 (2003) to 89.9 × 100,000 (2014) in men and from 64.3 to 58.4 × 100,000 in women. Among men, incidence decreased during 2007–2010 (APC −4.0, 95% CI −6.0 to −1.9) and 2010–2014 (APC −0.7, 95% CI −1.4 to 0.0), while in women it linearly decreased during the whole period (APC −1.1, 95% CI −1.4 to −0.8). Mortality rates showed a linear reduction both in men (APC −0.7, 95% CI −1.0 to −0.3) and women (APC −0.9, 95% CI −1.2 to −0.6) and decreased respectively from 41.1 to 39.2 × 100,000 and from 24.6 to 23.1 × 100,000. In the 50- to 69-year-old range (screening target age), incidence showed a prescreening increase, followed by a peak after screening started, and a decline thereafter. Incidence and mortality rates significantly decreased in all areas but in the south and islands, where incidence increased and mortality remained stable. Conclusions: A renewed commitment by all regional health systems to invest in primary (i.e., lifestyle) and secondary (i.e., screening programs) prevention is of utmost importance.