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FABIO VENTURELLA

Antiproliferative Oleanane Saponins from Meryta denhamii

  • Authors: CIOFFI, G; DAL PIAZ, F; VASSALLO, A; VENTURELLA, F; DE CAPRARIIS, P; DE SIMONE, F; DE TOMMASI, N
  • Publication year: 2008
  • Type: Articolo in rivista (Articolo in rivista)
  • Key words: Oleanane Saponins, Antiproliferative effects
  • OA Link: http://hdl.handle.net/10447/38990

Abstract

Eight new oleanane saponins (1- 8) together with four know saponins (9-12) were isolated from the aerial parts of Meryta denhamii. Their structures were elucidated by 1D and 2D NMR experiments including 1D TOCSY, DQF-COSY, ROESY, HSQC, and HMBC spectroscopy, as well as ESIMS analysis. The antiproliferative activity of all compounds was evaluated using three murine and human cancer cell lines: J774.A1, HEK-293, and WEHI-164.