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FABIO VENTURELLA

Bempedoic acid as adjunct for traditional lipid-lowering therapy in patients with hyperlipidaemia

  • Autori: Schimmenti C.; Sucato V.; Manzone E.; Cancellieri G.; Mortillaro F.; Novo G.; Galassi A.R.; Venturella F.
  • Anno di pubblicazione: 2021
  • Tipologia: Articolo in rivista
  • Parole Chiave: atherosclerosis; bempedoic acid; lipid-lowering therapy; low-density lipoprotein; statins
  • OA Link: http://hdl.handle.net/10447/513660

Abstract

Statin therapy has been the cornerstone for the reduction of cholesterol and circulating low-density lipoprotein (LDL) in patients with cardiovascular diseases. However, statin monotherapy has disadvantages attributable to myopathies and to the insufficient cholesterol reduction observed in some patients. There is a need for new well-tolerated therapies for lowering LDL. This review will focus on bempedoic acid in combination with traditional statin therapy or other lipid-lowering agents and its emerging role in LDL-C lowering. Bempedoic acid is also a viable alternative for reducing LDL cholesterol in the treatment of some patients suffering from heterozygous familial hypercholesterolemia.