A QSAR study investigating the potential anti-HIV-1 effect of some Acyclovir and Ganciclovir analogs
- Autori: Almerico, AM; Tutone, M; Lauria, A
- Anno di pubblicazione: 2009
- Tipologia: Articolo in rivista (Articolo in rivista)
- OA Link: http://hdl.handle.net/10447/45630
Abstract
A QSAR study, involving the use of alculated physical-chemical properties (TSARTM), and the use of a neural network approach (TSARTM), has been performed on the potential anti-HIV-1 activity of a series of Acyclovir and Ganciclovir analogs. Model obtained allows reliable predictions for the anti-HIV-1 activity of these derivatives, and showed that the presence of the Ganciclovir chain in triazolopyrrolopyrimidine and pyrimidopyrrolopyrimidine series seems to increase the antiviral effect.