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GIOVANNI TOMASELLO

CT-GUIDED TRANSTHORACIC NEEDLE BIOPSY: ADVANTEGES IN HISTOPATHOLOGICAL AND MOLECULAR TESTS

  • Autori: Porrello,C; Gullo,R; Gagliardo,MC; Vaglica,A; Palazzolo,M; Giangregorio,F; Iadicola,D; Catanzaro,A; Scerrino,G; Lo Faso,F; carini,F; Tomasello,G
  • Anno di pubblicazione: 2020
  • Tipologia: Articolo in rivista
  • OA Link: http://hdl.handle.net/10447/431412

Abstract

Aim: The present study aimed to demonstrate that computed tomography-guided transthoracic needle biopsy (TTNB) is a safe procedure that gives a more accurate pre-operative tissue diagnosis for peripheral lung nodules than transthoracic needle aspiration, obtaining suitable samples for molecular test in lung adenocarcinomas. Patients and methods: Between December 2016 and March 2018 at Thoracic Surgery Department of the University of Palermo - Policlinico Paolo Giaccone Hospital, TTNB was performed in 42 patients with computed tomography-detected peripheral lung nodules > 10 mm, using 16-18 -Gauge tru-Cut needles. Results: With TTNB, we have estimated an accuracy for tissue diagnosis of 97,6%. At the molecular test, EGFR overexpression and ALK mutation resulted positive for 12/23 patients with lung adenocarcinoma. Conclusion: TTNB has showed a low rate of complications and it is adoptable as standard diagnostic procedure for peripheral lung nodules.