Mesenchymal stem cells display hepato-protective activity in lymphoma bearing xenografts.
- Authors: Secchiero, P; Corallini, F; Zavan, B; Tripodo, C; Vindigni, V; Zauli, G.
- Publication year: 2012
- Type: Articolo in rivista (Articolo in rivista)
- OA Link: http://hdl.handle.net/10447/57801
Abstract
A disseminated model of non-Hodgkin's lymphoma with prevalent liver metastasis was generated by intraperitoneal (i.p.) injection of EBV(+) B lymphoblastoid SKW6.4 in nude-SCID mice. The survival of SKW6.4 xenografts (median survival = 27 days) was significantly improved when hyaluronan scaffolds embedded with mesenchimal stem cells (MSC) were implanted in the abdominal area 4 days after SKW6.4 injection (median survival = 39.5 days). Mice implanted with MSC showed a significant improvement of hepatic functionality in lymphoma xenografts, as demonstrated by measurement of serum ALT/AST levels. Co-culture of MSC with lymphoma cells enhanced the release of hepatocyte growth factor (HGF) by MSC. These data suggest that hyaluronan-embedded MSC exert anti-lymphoma activity by ameliorating hepatic functionality.