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NICOLA SCICHILONE

Asthma control in severe asthmatics under treatment with omalizumab: A cross-sectional observational study in Italy

  • Autori: Novelli F.; Latorre M.; Vergura L.; Caiaffa M.F.; Camiciottoli G.; Guarnieri G.; Matucci A.; Macchia L.; Vianello A.; Vultaggio A.; Celi A.; Cazzola M.; Paggiaro P.; Camiciottoli G.; Maselli R.; Pelaia G.; Busceti M.T.; Sabato E.; Cagnazzo M.G.; Colombo F.; Palumbo L.; Ravazzi A.; Bucca C.; Berra A.; Calabrese C.; Stanziola A.A.; Schino P.; Di Gioacchino M.; Cazzola M.; Segreti A.; Pastorello E.A.; Scibilia G.; Vianello A.; Marchi M.R.; Paladini L.; Baglioni S.; Abbritti M.; Almerigogna F.; Matucci A.; Vultaggio A.; Maggi E.; Maestrelli P.; Guarnieri G.; Steinhilber G.; Bonavia M.; Rottoli P.; Bargagli E.; Senna G.; Caminati M.; Macchia L.; Bellia V.; Scichilone N.; Paggiaro P.; Novelli F.; Vergura L.
  • Anno di pubblicazione: 2015
  • Tipologia: Articolo in rivista
  • OA Link: http://hdl.handle.net/10447/414974

Abstract

Few data are available on the proportion of asthmatics achieving a good asthma control (according GINA guidelines) and on the level of airway inflammation during omalizumab treatment.The aim of this cross-sectional national observational study was to assess the level of control (according to GINA guidelines) achieved in a group of asthmatics on omalizumab treatment, and to characterize the factors that influence the lack of control.We studied 306 asthmatics under omalizumab treatment for a median of 32 months (range 4-120). The level of control according to GINA was good in 25.2%, partial in 47.1% and poor in 24.5% of patients (data were missing for the remaining 3.2%). Comparison between poorly controlled and partially or well controlled asthmatics showed a statistically significant higher prevalence of some comorbidities in the first group, namely obesity, gastro-oesophageal reflux disease (GORD), aspirin intolerance and mental disorders (all p<0.001). Similarly, asthmatics with at least one exacerbation in the last year showed a significantly higher prevalence of obesity, chronic rhinosinusitis, nasal polyps, GORD, and aspirin intolerance (all p<0.05) than patients without exacerbations. When we selected patients without relevant comorbidities (upper airways disease, GORD, obesity, aspirin intolerance) and not currently smoking (. N=73), the percentage of well or partially controlled asthmatics was significantly higher than in patients with comorbidities (84.9% vs 71.1%, p=0.02); the rate of asthmatics without exacerbations in the last year was also higher (73.6% vs 51.1%, p=0.001).During omalizumab treatment, a high percentage of asthmatics obtain a good or partial control of asthma. Comorbidities are associated with the lack of asthma control and persistence of exacerbations.