C. HYSTOLITICUM RECOMBINANT COLLAGENASES AND METHOD FOR THE MANUFACTURE THEREOF
- Autori: Bertuzzi, F; Cuttitta, A; Ghersi, G; Mazzola, S; Salamone, M; Seidita, G;
- Anno di pubblicazione: 2010
- Tipologia: Brevetto
- Parole Chiave: COLLAGENASES; DIABET 1; CELL TERAPY; RECOMBINANT PROTEIN;
- OA Link: http://hdl.handle.net/10447/59868
The present invention relates to the production of recombinant collagenases, and in particular describes a method for the production of recombinant clostridium histolyticum collagenases Col characterized by a yield higher than approximately 140 mg/l of culture of said collagenases in soluble, biologically active form, collagenases produced by this method, compositions comprising these collagenases and the use thereof.