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NREM Sleep Instability in Pediatric Migraine Without Aura

  • Authors: Roccella, Michele; Marotta, Rosa; Operto, Francesca Felicia; Smirni, Daniela; Precenzano, Francesco; Bitetti, Ilaria; Messina, Giovanni; Sessa, Francesco; Di Mizio, Giulio; Loreto, Carla; Salerno, Monica; Russo, Vincenzo; Murabito, Paolo; Gallai, Beatrice; Esposito, Maria; Iacono, Diego; Carotenuto, Marco
  • Publication year: 2019
  • Type: Articolo in rivista
  • Key words: Cyclic alternating pattern (CAP) analysis; Full overnight polysomnography; Migraine without aura (MoA); NREM sleep instability; Sleep macrostructure;
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Children with migraine headaches appear to have a range of sleep disturbances. The aim of the present study was to assess the NREM sleep instability in a population of school-aged individuals affected by migraine without aura (MoA). Thirty-three children with MoA (20 males, 13 females, mean age 10.45 ± 2.06 years) underwent to overnight Polysomnographic (PSG) recordings and Cyclic Alternating Pattern (CAP) analyses accordingly with international criteria. MoA group showed a reduction in sleep duration parameters (TIB, SPT, TST; p ≤ 0.001 for all) and in arousal index during REM sleep and an increase in awakenings per hour (AWK/h) vs. Controls (C) (p = 0.008). In particular, MoA children showed a reduced CAP rate% (p ≤ 0.001), CAP rate% in S1 (p ≤ 0.001) and CAP rate% in SWS (p = 0.004) vs. C. Moreover, A phases distribution were characterized by a reduction in slow wave components (total number CAP A1%, CAP A1 index) (p ≤ 0.001) and an increase of fast components representation (total number of CAP A2% and CAP A3%) (p < 0.001) in MoA vs. C. Moreover, MoA children showed an increased A1 and A2 mean duration (p ≤ 0.001). Our findings show a reduction of arousability in MoA group and lower NREM lower sleep instability associated with MoA in children.