Predictors of insulin resistance in patients with obesity: a pilot study.

Abstract

We compared adipokines and inflammatory markers in obese insulin-sensitive (group A, n ¼ 16) and insulin-resistant (group B, n ¼ 48) patients divided according to homeostasis model assessment of insulin resistance (HOMA-IR). Serum levels of adiponectin, leptin, resistin, high-sensitivity C-reactive protein, interleukin 6, and tumor necrosis factor a were measured. Weight, height, waist (WC) and hip circumferences, waist to hip ratio , weight to height ratio, visceral adiposity index (VAI), and body adiposity index (BAI) were measured. The WC and VAI were significantly higher in group B (113.9 + 11.1 vs 105.3 + 9.8cm; P < .01 and 2.3 + 1.1 vs 1.6 + 0.9; P < .05, respectively), while serum adiponectin levels were higher in group A (24.5 + 14.6 vs 15.1 + 9.6 ng/mL; P < .005). The BAI strongly correlated with adiponectin and leptin in group B (r = .479; P < .001 and r = .705; P < .001). Insulin resistance is associated with visceral adiposity described by VAI and WC. The BAI may be a useful index in obese patients, especially with insulin resistance.