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ANTONIO RUSSO

Analysis of Ki-Ras mutations in stage I rectal carcinomas and respective regional lymph nodes.

  • Autori: Fiorentino, F.; Agnese, V.; Calò, V.; Bruno, L.; Augello, C.; Cascio, S.; Barbera, F.; Gargano, G.; Gregorio, V.; Calcara, D.; LA PAGLIA, L.; Schiro', V.; Terrasi, M.; Fanale, D.; Scolaro, L.; Graceffa, G.; DI GAUDIO, F.; Bazan, V.; Russo, A.; Agnello, G.
  • Anno di pubblicazione: 2007
  • Tipologia: Proceedings (TIPOLOGIA NON ATTIVA)
  • OA Link: http://hdl.handle.net/10447/13306

Abstract

In this work we show that the percentage of Ki-RAS mutations in codons 12 and 13 in rectal cancer are sensibly lower than in colon cancer, providing further evidence that these two kinds of tumors should be considered two different entities. Moreover, we show that the detection in regional lymph nodes of the same mutation of primary tumor might represent an indicator of lymph nodes metastasis in rectal carcinoma not detected in routine histologic examination.