Clinical features and comorbidity pattern of HCV infected migrants compared to native patients in care in Italy: A real-life evaluation of the PITER cohort
- Autori: Quaranta M.G.; Ferrigno L.; Tata X.; D'Angelo F.; Massari M.; Coppola C.; Biliotti E.; Giorgini A.; Laccabue D.; Ciancio A.; Blanc P.L.; Margotti M.; Ieluzzi D.; Brunetto M.R.; Barbaro F.; Russo F.P.; Beretta I.; Morsica G.; Verucchi G.; Saracino A.; Galli M.; Kondili L.A.; Mazzaro C.; Bertola M.; Benedetti A.; Schiada L.; Cucco M.; Giacometti A.; Brescini L.; Castelletti S.; Fiorentini A.; Angarano G.; Milella M.; Leo A.D.; Rendina M.; Salvatore D'ABRAMO F.; Lillo C.; Iannone A.; Piazzolla M.; Badia L.; Piscaglia F.; Benevento F.; Serio I.; Castelli F.; Zaltron S.; Spinetti A.; Odolini S.; Bruno R.; Mondelli M.; Chessa L.; Loi M.; Torti C.; Costa C.; Mazzitelli M.; Pisani V.; Scaglione V.; Trecarichi E.M.; Zignego A.L.; Monti M.; Madia F.; Attala L.; Pierotti P.; Salomoni E.; Mariabelli E.; Santantonio T.A.; Bruno S.R.; Cela E.M.; Bassetti M.; Mazzarello G.; Alessandrini A.I.; Biagio A.D.; Nicolini L.A.; Raimondo G.; Filomia R.; Aghemo A.; Meli R.; Lazzarin A.; Salpietro S.; Fracanzani A.L.; Fatta E.; Lombardi R.; Lampertico P.; Borghi M.; D'ambrosio R.; Degasperi E.; Puoti M.; Baiguera C.; D'AMICO F.; Vinci M.; Rumi M.G.; Zuin M.; Zermiani P.; Andreone P.; Caraceni P.; Guarneri V.; Villa E.; Bernabucci V.; Bristot L.; Paradiso M.L.; Migliorino G.; Gambaro A.; Lapadula G.; Spolti A.; Soria A.; Invernizzi P.; Ciaccio A.; LucA M.; Malinverno F.; Ratti L.; Amoruso D.C.; Pisano F.; Scarano F.; Staiano L.; Morisco F.; Cossiga V.; Gentile I.; Buonomo A.R.; Foggia M.; Zappulo E.; Federico A.; Dallio M.; Coppola N.; Sagnelli C.; Martini S.; Monari C.; Nardone G.; Sgamato C.; Chemello L.; Cavalletto L.; Sterrantino D.; Zanetto A.; Zanaga P.; Brancaccio G.; Craxi A.; Petta S.; Calvaruso V.; Crapanzano L.; Madonia S.; Cannizzaro M.; Bruno E.M.; Licata A.; Amodeo S.; Capitano A.R.; Ferrari C.; Negri E.; Orlandini A.; Pesci M.; Gulminetti R.; Pagnucco L.; Parruti G.; Stefano P.D.; Coco B.; Corsini R.; Garlassi E.; Andreoni M.; Teti E.; Cerva C.; Baiocchi L.; Grassi G.; Gasbarrini A.; Pompili M.; Siena M.D.; Taliani G.; Spaziante M.; Persico M.; Masarone M.; Aglitti A.; Calvanese G.; Anselmo M.; Leo P.D.; Marturano M.; Saracco G.M.
- Anno di pubblicazione: 2021
- Tipologia: Articolo in rivista
- OA Link: http://hdl.handle.net/10447/535380
Abstract
Background: Direct-acting antivirals are highly effective for the treatment of hepatitis C virus (HCV) infection, regardless race/ethnicity. We aimed to evaluate demographic, virological and clinical data of HCV-infected migrants vs. natives consecutively enrolled in the PITER cohort. Methods: Migrants were defined by country of birth and nationality that was different from Italy. Mann-Whitney U test, Chi-squared test and multiple logistic regression were used. Results: Of 10,669 enrolled patients, 301 (2.8%) were migrants: median age 47 vs. 62 years, (p < 0.001), females 56.5% vs. 45.3%, (p < 0.001), HBsAg positivity 3.8% vs. 1.4%, (p < 0.05). Genotype 1b was prevalent in both groups, whereas genotype 4 was more prevalent in migrants (p < 0.05). Liver disease severity and sustained virologic response (SVR) were similar. A higher prevalence of comorbidities was reported for natives compared to migrants (p < 0.05). Liver disease progression cofactors (HBsAg, HIV coinfection, alcohol abuse, potential metabolic syndrome) were present in 39.1% and 47.1% (p > 0.05) of migrants and natives who eradicated HCV, respectively. Conclusion: Compared to natives, HCV-infected migrants in care have different demographics, HCV genotypes, viral coinfections and comorbidities and similar disease severity, SVR and cofactors for disease progression after HCV eradication. A periodic clinical assessment after HCV eradication in Italians and migrants with cofactors for disease progression is warranted.