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GIOVANNA PITARRESI

BIOADHESIVE PROPERTIES OF A POLYAMINOACIDIC HYDROGEL: EVALUATION BY ATR FT-IR SPECTROSCOPY

  • Autori: Saiano, F.; Pitarresi, G.; Mandracchia, D.; Giammona, G.
  • Anno di pubblicazione: 2005
  • Tipologia: Articolo in rivista

Abstract

The bioadhesive properties of a novel chemical hydrogel based on a polymer of protein-like structure, have been investigated by using ATR FT-IR spectroscopy. In particular, the copolymer PHG obtained by partial derivatization of PHEA with GMA was chemically crosslinked by UVirradiation at 313 nm. Crosslinked PHG was treated with water to obtain a swelled sample, named PHG-UV gel, that was brought into contact with a phosphate buffer/citric acid solution at pH 7.0 in the absence or in the presence of mucin at various concentrations (0.01, 0.1 and 1 wt.-%). Preliminary dynamic swelling studies have evidenced the occurrence of an interaction between thePHG-UVgel and the glycoprotein. This result was confirmed by ATR FT-IR measurements. A diffusion model using a solution of Ficks’ second law was employed to determine the diffusion coefficient of water into PHG-UV gel as a consequence of adsorption and/or interdiffusion which occur at the PHG-UV gel/mucin solution interface. Experimental results suggest a potential use of PHG-UV gel to prepare bioadhesive devices.