Synthesis, chemical characterization and preliminary in vitro antitumor activity evaluation of new ruthenium(II) complexes with sugar derivatives
- Autori: Fontana, G; Abbate, M; Casella, G; Pellerito, C; Longo, A; Ferrante, F
- Anno di pubblicazione: 2011
- Tipologia: Articolo in rivista (Articolo in rivista)
- OA Link: http://hdl.handle.net/10447/74651
Abstract
Three new complexes of Ru(II), namely [RuCl2(Glun-N,O)2]Na2 (I; Glun = glucosaminate), [RuCl2(1- Tglu)(EtOH)2]Na (II; 1-Tglu = 1-thio-b-D-glucose) and [Ru2(EtOH)6(AL)Cl4] (III; AL=60-aminolactose) were prepared from the same Ru(II) precursor, [RuCl2(DMSO)4] (DMSO = dimethyl sulfoxide). The characterization of the complexes was carried out by elemental analysis, FT-IR, ES-MS, NMR, EXAFS and DFT calculations. The effectiveness of the complexes on metastatic melanoma A 375 was investigated. The results show that complex II is the most active species.