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Multicenter validation of the magnetic resonance T2* technique for segmental and global quantification of myocardial iron.

  • Authors: Ramazzotti, A.; Pepe, A.; Positano, V.; Rossi, G.; De Marchi, D.; Brizi, M.; Luciani, A.; Midiri, M.; Sallustio, G.; Valeri, G.; Caruso, V.; Centra, M.; Cianciulli, P.; De Sanctis, V.; Maggio, A.; Lombardi, M.
  • Publication year: 2009
  • Type: Articolo in rivista (Articolo in rivista)
  • Key words: myocardial iron; T2* technique;
  • OA Link:


PURPOSE: To assess the transferability of the magnetic resonance imaging (MRI) multislice multiecho T2(*) technique for global and segmental measurement of iron overload in thalassemia patients. MATERIALS AND METHODS: Multiecho T2(*) sequences were installed on six MRI scanners. Five healthy subjects (n = 30) were scanned at each site; five thalassemia major (TM) patients were scanned at the reference site and were rescanned locally (n = 25) within 1 month. T2(*) images were analyzed using previously validated software. RESULTS: T2(*) values of healthy subjects showed intersite homogeneity. On TM patients, for global heart T2(*) values the correlation coefficient was 0.97, coefficients of variation (CoV(s)) ranged from 0.04-0.12, and intraclass coefficients (ICC(s)) ranged from 0.94-0.99. The mean CoV and ICC for segmental T2(*) distribution were 0.198 and 88, respectively. CONCLUSION: The multislice multiecho T2(*) technique is transferable among scanners with good reproducibility. (c) 2009 Wiley-Liss, Inc.