A radical signal activates the epigenetic regulation of longevity
- Autori: Mirisola, MG; Longo, VD
- Anno di pubblicazione: 2013
- Tipologia: Articolo in rivista (Articolo in rivista)
- Parole Chiave: epigenetic, stress resistance, hormesis
- OA Link: http://hdl.handle.net/10447/100672
Abstract
Hormesis is an adaptive stress response implicated in longevity regulation. Schroeder et al. (2013) have now connected stress, epigenetic changes, and aging in yeast by showing that mitochondria-derived reactive oxygen species modulate the chromatin binding capacity of the histone demethylase Rph1p at subtelomeres, resulting in lifespan extension.