Hyperuricemia and high blood pressure at rest and during exercise: Guilty or innocent? The jury is still out

Abstract

(First sentences of the paper that has not abstract). Uric acid (UA) is generated as part of the normal turnover of nucleic acid. Purine bases and their nucleotides are captured by the liver and converted into xanthines, metabolized by UA, or recycled by salvage pathways or de novo synthesis. UA formation by xanthine occurs via hypoxanthine by the action of xanthine oxidase (XO), an enzyme present in the peroxisomes of most cells, which is an im-portant source of reactive oxygen species involved in various forms of ischemic and other types of vascular injuries and chronic heart failure. ....