PSA reduction (after antibiotics) permits to avoid or postpone prostate biopsy in selected patients
- Autori: SERRETTA, V; CATANESE, A; DARICELLO, G; LIOTTA, R; ALLEGRO, R; MARTORANA, A; MELLONI, D
- Anno di pubblicazione: 2008
- Tipologia: Articolo in rivista (Articolo in rivista)
- Parole Chiave: prostate-specific antigen (PSA), prostatitis, prostate carcinoma
- OA Link: http://hdl.handle.net/10447/47165
Abstract
Microscopic foci of prostatitis may induce prostate-specific antigen (PSA) increase. PSA reduction after antibiotics might identify those patients in whom biopsy can be avoided. Ninety-nine patients received ciprofloxacin for 3 weeks, of whom 59 showed PSA reduction. Histology detected small foci of prostatitis in 65% of cases. Carcinoma was found in 40 and 20.3% of patients with unchanged or decreased PSA, respectively (P=0.03). No cancer was detected if PSA decreased below 4 ng/ml or more than 70%. Biopsy can be postponed, with a low risk of missing a cancer, if PSA decreases more than 70% or below 4 ng/ml.