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PAOLO MARIA GIUSEPPE LO MEO

1,2,3-Oligotriazoles modified halloysite nanotubes as potential active biological species: synthesis and characterization

  • Authors: Massaro, Marina; Colletti, Carmelo Giuseppe; Cavallaro, Giuseppe; Lazzara, Giuseppe; Meo, Paolo Lo; Riela, Serena; Noto, Renato
  • Publication year: 2022
  • Type: Articolo in rivista
  • OA Link: http://hdl.handle.net/10447/533776

Abstract

In the last years, the development of nano-formulations for cancer treatment represents one of the major challenges of the scientific research. The prodrug strategy, that combines chemotherapeutic agents with nanocarriers such as halloysite nanotubes (HNTs), is a promising strategy both to improve the biological activity of the drug molecules and to reduce the side effects of drugs. Herein we report the synthesis and characterization of a HNTs prodrug based on 1,2,3-triazole units covalently linked to HNTs external surface, bearing different positively charged moieties, which could present interesting pharmacological activities.