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MARIANNA LAURICELLA

Synthesis and antirpoliferative activity of isoxazolo[3,4-d]pyridazin-7(6H)-one derivatives

  • Authors: Maggio, B; Cancemi, G; Raimondi, MV; Plescia, F; Cascioferro, SM; Cusimano, MG; Lauricella, M; Carlisi, D; Daidone, G; Raffa, D
  • Publication year: 2014
  • Type: eedings
  • OA Link: http://hdl.handle.net/10447/98586

Abstract

3,4-diphenylisoxazolo[3,4-d]pyridazin-7(6H)-one analogs were synthesized and tested for the antiproliferative activity. Study on the cell cycle alteration and on some cellular target (ATM, procaspase-2 proteins and H2AX histone) demonstrate the increase of the cell population in S phase and to induce cellular death by apoptosis by DNA damage with double strand breaks.