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Targeting of the Peritumoral Adipose Tissue Microenvironment as an Innovative Antitumor Therapeutic Strategy

  • Autori: Lo Iacono M.; Modica C.; Porcelli G.; Brancato O.R.; Muratore G.; Bianca P.; Gaggianesi M.; Turdo A.; Veschi V.; Todaro M.; Di Franco S.; Stassi G.
  • Anno di pubblicazione: 2022
  • Tipologia: Review essay (rassegna critica)
  • OA Link:


The tumor microenvironment (TME) plays a key role in promoting and sustaining cancer growth. Adipose tissue (AT), due to its anatomical distribution, is a prevalent component of TME, and contributes to cancer development and progression. Cancer-associated adipocytes (CAAs), reprogrammed by cancer stem cells (CSCs), drive cancer progression by releasing metabolites and inflammatory adipokines. In this review, we highlight the mechanisms underlying the bidirec-tional crosstalk among CAAs, CSCs, and stromal cells. Moreover, we focus on the recent advances in the therapeutic targeting of adipocyte-released factors as an innovative strategy to counteract cancer progression.