Salta al contenuto principale
Passa alla visualizzazione normale.

MICHELANGELO GRUTTADAURIA

Lipase-catalyzed resolution of anti-substituted 1,3-dioxepan-5-ols

  • Autori: Gruttadauria, M.; LO MEO, P.; Riela, S.; Giacalone, F.; Noto, R.
  • Anno di pubblicazione: 2006
  • Tipologia: Articolo in rivista (Articolo in rivista)
  • OA Link: http://hdl.handle.net/10447/19304

Abstract

Several anti-6-substituted 1,3-dioxepan-5-ols were kinetically resolved using an immobilized lipase (Amano PS–C II) in toluene in the presence of vinyl acetate at 30 C. This approach provided, in some cases, the alcohol and the acetate in high enantiomeric purity, depending on the nature of the substituent (R = N3, SePh, I, OBn) and the acetal group (unsubstituted or dimethyl). The role of the size of substituents is also discussed. Enantiopure anti-6-substituted 1,3-dioxepan-5-ols are useful building blocks.