IL-17 polarization of MAIT cells is derived from the activation of two different pathways
- Autori: Guggino, G.; Liberto, D.; Pizzo, M.; Saieva, L.; Alessandro, R.; Dieli, F.; Triolo, G.; Ciccia, F.
- Anno di pubblicazione: 2017
- Tipologia: Articolo in rivista (Articolo in rivista)
- Parole Chiave: IL-17; IL-23; IL-7; MAIT cells; RORc; Sjogren's Syndrome; STAT3; Immunology and Allergy; Immunology
- OA Link: http://hdl.handle.net/10447/245512
Abstract
MAIT cells are expanded in salivary glands of patients with Sjogren's syndrome and are IL-17 polarized. IL-7 and IL-23 induce IL-17 production activating two different pathways: IL-7 stimulation induces in fact a significant STAT3 and HIF1alpha upregulation, conversely, IL-23 stimulation significantly induces RORc overexpression in MAIT cells of patients with Sjogren's syndrome.