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GIOVANNI GRASSO

Exploring the Virchow-Robin spaces function: A unified theory of brain diseases

  • Autori: Cherian, I.; Beltran, M.; Kasper, E.M.; Bhattarai, B.; Munokami, S.; Grasso, G.
  • Anno di pubblicazione: 2016
  • Tipologia: Articolo in rivista
  • OA Link: http://hdl.handle.net/10447/414262

Abstract

Background: Cerebrospinal fluid (CSF) transport across the central nervous system (CNS) is no longer believed to be on the conventional lines. The Virchow-Robin space (VRS) that facilitates CSF transport from the basal cisterns into the brain interstitial fluid (ISF) has gained interest in a whole new array of studies. Moreover, new line of evidence suggests that VRS may be involved in different pathological mechanisms of brain diseases. Methods: Here, we review emerging studies proving the feasible role of VRS in sleep, Alzheimer's disease, chronic traumatic encephalopathy, and traumatic brain injury (TBI). Results: In this study, we have outlined the possible role of VRS in different pathological conditions. Conclusion: The new insights into the physiology of the CSF circulation may have important clinical relevance for understanding the mechanisms underlying brain pathologies and their cure. ©2016 Surgical Neurology International | Published by Wolters Kluwer - Medknow .