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Real-time PCR for early diagnosis of Rickettsia conorii and prompt management in patients with septic shock and multiple organ failure: two case reports

  • Autori: DI CARLO, P.; Trizzino, M.; Giarratano, A.; Giammanco, A.; Montalto, F.; Raineri, S.; Dones, P.; Bonura, C.
  • Anno di pubblicazione: 2015
  • Tipologia: Articolo in rivista (Articolo in rivista)
  • OA Link:


We herein describe two severe cases of Mediterranean spotted fever caused by Rickettsia conorii. The ar- ticle presents polymerase chain reaction-restriction analysis as an early diagnostic tool for rickettsiosis caused by spotted fever group Rickettsiae. Timely microbiological diagnosis, the combined use of antibi- otics, intensive care measures and a multidisciplinary team approach are fundamental to manage these serious diseases.