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VALENTINA DI FELICE

Identification and characterization of the nano-sized vesicles released by muscle cells

  • Autori: Romancino, D.; Paterniti, G.; Campos, Y.; DE LUCA, A.; DI FELICE, V.; D'Azzo, A.; Bongiovanni, A.
  • Anno di pubblicazione: 2013
  • Tipologia: Articolo in rivista (Articolo in rivista)
  • OA Link: http://hdl.handle.net/10447/75974

Abstract

Several cell types secrete small membranous vesicles that contain cell-specific collections of proteins, lipids, and genetic material. The function of these vesicles is to allow cell-to-cell signaling and the horizontal transfer of their cargo molecules. Here, we demonstrate that muscle cells secrete nano-sized vesicles and that their release increases during muscle differentiation. Analysis of these nanovesicles allowed us to characterize them as exosome-like particles and to define the potential role of the multifunctional protein Alix in their biogenesis.