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PATRIZIA DIANA

Pyrido[2’,3’:4,5]pyrrolo[2,1-d][1,2,3,5]tetrazine-4(3H)-ones, a new class of temozolomide heteroanalogues

  • Autori: DIANA, P; STAGNO, A; BARRAJA, P; MONTALBANO, A; MARTORANA, A; CARBONE, A; DATTOLO, G; CIRRINCIONE, G
  • Anno di pubblicazione: 2009
  • Tipologia: Articolo in rivista (Articolo in rivista)
  • Parole Chiave: Temozolomide Mitozolomide, pyrrolo[2,1-d][1,2,3,5]tetrazinones; Antitumor activity, pyrido[2’,3’:4,5]pyrrolo[2,1-d][1,2,3,5]tetrazines
  • OA Link: http://hdl.handle.net/10447/45618

Abstract

Twelve derivatives of new ring system pyrido[2’,3’:4,5]pyrrolo[2,1-d][1,2,3,5]tetrazine were prepared in good yields by reaction of 2-diazo-3-ethoxycarbonyl-pyrrolo[3,2-b]pyridine with alkyl- or aryl-isocyanates. Nine derivatives, screened by the National Cancer Institute (Bethesda, MD) for the in vitro one dose primary anticancer assay against a panel of about 60 human tumor cell lines, showed no significant activity.