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PATRIZIA DIANA

Synthesis of [1,2]oxazolo[5,4-e]indazoles as antitumour agents

  • Autori: Barraja, P; Spano, V; Giallombardo, D; Diana, P; Montalbano, A; Carbone, A; Parrino, B; Cirrincione, G
  • Anno di pubblicazione: 2013
  • Tipologia: Articolo in rivista (Articolo in rivista)
  • Parole Chiave: [1,2]Oxazolo[5,4-e]indazoles, Enaminoketones, Hydroxylamine hydrochloride, Antiproliferative activity
  • OA Link: http://hdl.handle.net/10447/80223

Abstract

A series of 40 derivatives of the [1,2]oxazolo[5,4-e]indazoles ring system have been prepared with good yields using a versatile and convenient route. Annelation of the [1,2]oxazole ring on the indazole-4-one system was achieved by reaction of the corresponding enaminoketones with hydroxylamine hydrochloride. Derivatives of the title ring system were tested by the National Cancer Institute of Bethesda and one of them (13t) showed growth-inhibitor activity against all the 54 human tumour cell lines generally at low micromolar concentrations.