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Synthesis and antifungal activity of new N-isoxazolyl-2-iodobenzamides

  • Autori: Raffa, D.; Daidone, G.; Maggio, B.; Schillaci, D.; Plescia, F.; Torta, L.
  • Anno di pubblicazione: 1999
  • Tipologia: Articolo in rivista (Articolo in rivista)


N-Isoxazolyl-2-iodobenzamides 3 and 9, with a benodanil-like structure, were synthesized by refluxing in acetic acid the corresponding benzotriazinones 2 and 8 with potassium iodide for 1 h with the aim to ascertain if they were active as fungicides against Phytophthora citricola Saw., Botrytis cinerea Pers., Rhizoctonia sp. and Alternaria sp. Among the tested iodo derivatives, compounds 3b and 9a possess interesting activities against the aforesaid fungal strains in several cases similar to that of benodanil I taken as reference drug.