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FRANCESCO DIELI

CXCR5 identifies a subset of Vgamma9 Vdelta2 T cells which secrete IL-4 and IL-10 and help B cells for antibody production.

  • Authors: CACCAMO, N; BATTISTINI, L; BONNEVILLE, M; POCCIA, F; FOURNIE', JJ; MERAVIGLIA, S; BORSELLINO, G; KROCZEK, RA; LA MENDOLA, C; SCOTET, E; DIELI, F; SALERNO, A
  • Publication year: 2006
  • Type: Articolo in rivista
  • Key words: Vgamma9Vdelta2 T lymphocytes, CXCR5, Help B cells
  • OA Link: http://hdl.handle.net/10447/23163

Abstract

Vgamma9Vdelta2 T lymphocytes recognize nonpeptidic Ags and mount effector functions in cellular immune responses against microorganisms and tumors, but little is known about their role in Ab-mediated immune responses. We show here that expression of CXCR5 identifies a unique subset of Vgamma9Vdelta2 T cells which express the costimulatory molecules ICOS and CD40L, secrete IL-2, IL-4, and IL-10 and help B cells for Ab production. These properties portray CXCR5+ Vgamma9Vdelta2 T cells as a distinct memory T cell subset with B cell helper function.