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CLELIA DISPENZA

Gadolinium-chelating nanogels as MR contrast agesnts specifically targeting tumor cells

  • Autori: PARDO, S; DISPENZA, C; SABATINO, M.A.; AJOVALASIT, A.; JONSSON, M
  • Anno di pubblicazione: 2014
  • Tipologia: eedings
  • OA Link: http://hdl.handle.net/10447/95592

Abstract

Development of multifunctional nanogels coordinating paramagnetic ions and displacing targeting ligands for preferential accumulation into tumors. Low molecular-weight Gd-chelates are widely used in clinical MRI for various purposes. However, these contrast agents (CAs) have several shortcomings: they rapidly extravasate from blood vessels to the interstitial space, have a short circulation times and show poor contrast at high magnetic fields. Incorporating gadolinium into flexible nanogels has the potential of increasing intravascular half-life, accumulation and retention in specific body compartments of the CA as well as increasing the MR signal, since many metal ions can be coordinated to the same nanoparticle