Gene therapy for type 1 diabetes: is it ready for the clinic?
- Autori: D'ANNEO A; ROOD P; BOTTINO R; BALAMURUGAN AN; HE J; GIANNOUKAKIS N
- Anno di pubblicazione: 2006
- Tipologia: Articolo in rivista (Articolo in rivista)
- Parole Chiave: Diabetes; Gene therapy; Immunotherapy; Autoimmunity.
- OA Link: http://hdl.handle.net/10447/25215
Abstract
This review, in addition to updating the growing list of type 1 diabetes–relevant gene therapies, offers an outline of short-term objectives that can readily be met to move, at least, adenoviral and adeno-associated viral-based protocols into the clinic, first as a means of facilitating islet allografts as well as platforms with which to introduce immunoregulatory transgenes. A wide array of genes have been tested to restore insulin production, to drive the differentiation of insulin-producing progenitors, and to confer immunosuppression in an antigen- and tissue-restricted manner.