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MARCELLO CIACCIO

Fetun-A and end stage renal disease: correlations with haemodialytic single session and genotype

  • Autori: BIVONA, G; LO SASSO, B; CARUSO, A; LIGA, L; MIGLIORISI, C; MAIORANA, P; RAINERI, R; CIACCIO, M
  • Anno di pubblicazione: 2011
  • Tipologia: Capitolo o Saggio (Capitolo o saggio)
  • Parole Chiave: Fetuin- A, End Stage Renal Disease, cardiovascular disease, inflammation
  • OA Link: http://hdl.handle.net/10447/66228

Abstract

Several studies showed that Fetuin-a is an extracellular calcium-regulatory protein acting as a potent inhibitor of calcium-phosphate precipitation, involved also in bone metabolism because of its high affinity for hydroxyapatite. The aim of this study is to evaluate the serum Fetuin-A levels in patients with chronic renal failure before and after a single session of dialysis and to investigate the correlation between protein serum concentrations and T256S genotype. Our results show that serum Fetuin- A levels decrease 4 hours after haemodialysis treatment and a significant correlation between 256SS homozygote and serum protein levels. Ectopic calcification and particularly intravascular calcification is inhibited by Fetuin-A and this mechanism seems to be of some importance in cardiovascular morbidity and mortality in patients with End Stage Renal Disease (ESRD).