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GIUSEPPINA CANDORE

The role of immune response in ageing and longevity. A focus on B cell compartment

  • Authors: Bulati, M.; Caruso, C.; Candore, G.; Colonna Romano Giuseppina,
  • Publication year: 2017
  • Type: Contributo in atti di convegno pubblicato in volume
  • OA Link: http://hdl.handle.net/10447/251203

Abstract

The improvement of the quality of life of elderly people is going to become a priority because of the continuous increase in the number of centenarians. This render the studies of the processes involved in ageing of critical importance. Centenarians are a widely accepted model of successful ageing, a complex process which is influenced by several biological, environmental and lifestyle factors, because they have reached the extreme limits of life span overcoming the major age-related diseases. In centenarians model, several aspects have been studied, as inflammation, immune system, genetics and metabolism, to understand the secret of their long survival. It has been proposed that centenarians are characterized by more efficient protective molecules and biochemical pathways, and show well preserved immune functions.