Immune profiling of Alzheimer patients
- Autori: Pellicanò, M; Larbi, A; Goldeck, D; Colonna-Romano, G; Buffa, S; Bulati, M; Rubino, G; Iemolo, F; Candore, G; Caruso, C; Derhovanessian, E; Pawelec, G
- Anno di pubblicazione: 2012
- Tipologia: Articolo in rivista (Articolo in rivista)
- Parole Chiave: Alzheimer's disease; T cells; Aβ42; Immunosenescence
- OA Link: http://hdl.handle.net/10447/73499
Abstract
Alzheimer's disease (AD) is characterized by extracellular senile plaques in the brain, containing amyloid-β peptide (Aβ). We identify immunological differences between AD patients and age-matched controls greater than those related to age itself. The biggest differences were in the CD4+ rather than the CD8+ T cell compartment resulting in lower proportions of naïve cells, more late-differentiated cells and higher percentages of activated CD4+CD25+ T cells without a Treg phenotype in AD patients. Changes to CD4+ cells might be the result of chronic stimulation by Aβ present in the blood. These findings have implications for diagnosis and understanding the aetiology of the disease