A single amino acid change A19V in perforin: a novel, frequent predisposing factor to childhood acute lymphoblastic leukemia?
- Autori: SANTORO A; CANNELLA S TRIZZINO A; LO NIGRO L; CORSELLO G; ARICO M
- Anno di pubblicazione: 2005
- Tipologia: Articolo in rivista (Articolo in rivista)
- Parole Chiave: A91V, Childhood acute lymphoblastic leukemia, Perrforin
- OA Link: http://hdl.handle.net/10447/23242
Abstract
We screened 100 children with acute lymphoblastic leukemia (ALL) to assess the incidence of single amino acid change A91V in perform. Heterozygous A91V was found in 12/100 patients and 5/127 controls (OR, 3.4; 95%CI: 1.15-9.95; p=0.014). A91V is a novel and frequent predisposing factor for childhood ALL.