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GENNARA CAVALLARO

Production of polymeric micro- and nanostructures with tunable properties as pharmaceutical delivery systems

  • Autori: Emanuela F. Craparo , Salvatore E. Drago , Gaetano Giammona , Gennara Cavallaro
  • Anno di pubblicazione: 2020
  • Tipologia: Articolo in rivista
  • OA Link: http://hdl.handle.net/10447/423478

Abstract

The production of novel graft copolymers based on poly-ε-caprolactone (PCL) and polyaspartamide are useful to realize structures for potential biomedical applications. Here, the synthesis of pegylated PCL/polyhydroxyethyl aspartamide (PHEA) graft copolymers (PHEA-g-SUCC-PCL-g-PEG) with tunable composition, was achieved by followpling a synthetic strategy that involved first the grafting of preformed PCL on PHEA backbone, then polyethylen glycol (PEG), by using 1,10 -carbonyldiimidazole (CDI) to speed up the condensation reaction. Graft copolymers with a Derivatization Degree (DD) in PCL ranging between 1.1 and 4.4 mol% were obtained, and processable with different technologies for the realization of micro- and nanostructures for biomedical applications. Pegylated graft copolymers, PHEA-g-SUCC-PCL-g-PEG, with a DDPEG of about 3.9 mol% were synthesized, and starting from these materials, structures such as fibers, micro- and nanoparticles were produced by different methods, such as microfluidics and nanoprecipitation.