Increased expression of transketolase-like-1 in papillary thyroid carcinomas smaller than 1.5 cm in diameter is associated with lymph-node metastases.
- Autori: ZERILLI, M; AMATO, MC; MARTORANA, A; CABIBI, D; COY, JF; CAPPELLO, F; POMPEI, G; RUSSO, A; GIORDANO, C; RODOLICO, V
- Anno di pubblicazione: 2008
- Tipologia: Articolo su rivista (Articolo in rivista)
BACKGROUND: Patients with small papillary thyroid carcinoma (PTC) may have a high incidence of regional lymph-node (LN) metastases at presentation, and these are considered to be an independent risk factor for tumor recurrence. A mutated transketolase transcript (TKTL1) has been found up-regulated in different human malignancies, and strong TKTL1 protein expression has been associated with aggressiveness and poor patient survival in several epithelial cancers. METHODS: TKTL1 protein expression was analyzed in 256 consecutive cases of PTCs