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FRANCESCO CAPPELLO

ADULT STEM CELLS: THE REAL ROOT INTO THE EMBRYO?

  • Autori: Zummo, G.; Bucchieri, F.; Cappello, F.; Bellafiore, M.; LA ROCCA, G.; David, S.; DI FELICE, V.; Anzalone, R.; Peri, G.; Palma, A.; Farina, F.
  • Anno di pubblicazione: 2007
  • Tipologia: Articolo in rivista (Articolo in rivista)
  • Parole Chiave: stem cell

Abstract

During embryonic development, a pool of cells may become a reserve of undifferentiated cells, the embryo-stolen adult stem cells (ESASC). ESASC may be responsible for adult tissue homeostasis, as well as disease development. Transdifferentiation is a sort of reprogramming of ESASC from one germ layer-derived tissue towards another. Transdifferentiation has been described to take place from mesoderm to ectodermal- or endodermal-derived tissues and viceversa but not from ectodermal- to endodermal-derived tissues. We hypothesise that two different populations of ESASC could exist, the first ecto/mesoblast-committed and the second endo/mesoblast-committed. If confirmed, this hypothesis could lead to new studies on the molecular mechanisms of cell differentiation and to a better understanding of the pathogenesis of a number of diseases.

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