ADULT STEM CELLS: THE REAL ROOT INTO THE EMBRYO?
- Autori: ZUMMO, G; BUCCHIERI, F; CAPPELLO, F; BELLAFIORE, M; LA ROCCA, G; DAVID, S; DI FELICE, V; ANZALONE, R; PERI, G; PALMA, A; FARINA, F
- Anno di pubblicazione: 2007
- Tipologia: Articolo su rivista (Articolo in rivista)
- Parole Chiave: stem cell
During embryonic development, a pool of cells may become a reserve of undifferentiated cells, the embryo-stolen adult stem cells (ESASC). ESASC may be responsible for adult tissue homeostasis, as well as disease development. Transdifferentiation is a sort of reprogramming of ESASC from one germ layer-derived tissue towards another. Transdifferentiation has been described to take place from mesoderm to ectodermal- or endodermal-derived tissues and viceversa but not from ectodermal- to endodermal-derived tissues. We hypothesise that two different populations of ESASC could exist, the first ecto/mesoblast-committed and the second endo/mesoblast-committed. If confirmed, this hypothesis could lead to new studies on the molecular mechanisms of cell differentiation and to a better understanding of the pathogenesis of a number of diseases.