Salta al contenuto principale
Passa alla visualizzazione normale.

EGLE CORRADO

RUPTURE OF THE ATHEROSCLEROTIC PLAQUE: IS CHLAMYDIA PNEUMONIAE A POSSIBLE AGENT?

  • Autori: FAZIO G; ZITO R; CASCIO C; BRIGUGLIA D; CORRADO E; ASSENNATO P; HOFFMANN E; NOVO S
  • Anno di pubblicazione: 2006
  • Tipologia: eedings
  • OA Link: http://hdl.handle.net/10447/26411

Abstract

BACKGROUND: The natural history of atherosclerosis has not clearly been elucidated yet. Some works reported that flogosis plays a role in plaque instability. Why does this inflammatory process start? We investigated the correlation between Chlamydia pneumoniae acute infection and plaque rupture. METHODS: We compared blood concentrations of IgM anti-Chlamydia pneumoniae in patients affected by acute myocardial infarction (AMI) and in patients affected by stable angina. RESULTS: Our results showed a minimal statistical difference, with a more positive value in patients with AMI. Subsequently, the group affected by AMI was divided into two subgroups with and without plaque rupture: the subgroup with plaque rupture showed a higher blood concentration of Chlamydia antibodies. This subgroup was also divided into two other subgroups according to blood white cell concentration: the subgroup with normal concentration of white blood cells showed the highest value of Chlamydia antibodies. CONCLUSIONS: Chlamydia pneumoniae could play an important role in atherosclerotic plaque instability