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ANTONIO CASCIO

SHORT COURSE TREATMENT OF VISCERAL LEISHMANIASIS WITH LIPOSOMAL AMPHOTERICIN B (AmBisome)

  • Authors: DAVIDSON R.N; DI MARTINO L; GRADONI L; GIACCHINO R; GAETA GB; PEMPINELLO R; SCOTTI S; A. CASCIO; CASTAGNOLA E; MAISTO A; GRAMICCIA M; DI CAPRIO D
  • Publication year: 1996
  • Type: Articolo in rivista
  • OA Link: http://hdl.handle.net/10447/384845

Abstract

We evaluated liposomal amphotericin B (AmBisome; Vestar, San Dimas, CA) administered to 88 immunocompetent patients (56 children) with visceral leishmaniasis (VL) caused by Leishmania infantum. Thirteen patients received 4 mg/kg on days 1-5 and 10 (total dose, 24 mg/kg), and all were cured; 42 received 3 mg/kg on days 1-5 and 10 (18 mg/kg), and 41 were cured; 32 received 3 mg/kg on days 1-4 and 10 (15 mg/kg), and 29 were cured (amastigotes were not cleared from 1 child, and 2 relapsed). One adult was cured with a total dose of 12mg/kg. The four children who were not cured received 3 mg/kg for 10 days; none had further relapses. There were no significant adverse events. For VL due to L. infantum, we recommended a total dose of AmBisome of > or = 20 mg/kg, given in > or = 5 doses of 3-4 mg/kg over > or = 10 days.